RNA-binding protein 9; RNA-binding motif protein 9; Fox-1 homolog B; hexaribonucleotide-binding protein 2; repressor of tamoxifen transcriptional activity (RBM9, FOX2, RBFOX2, HRNBP2, RTA)

Function

• RNA-binding protein
• regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements
• prevents binding of U2AF2 to the 3'-splice site
• regulates alternative splicing of tissue-specific exons & of differentially spliced exons during erythropoiesis (putative)
• seems to act as a coregulatory factor of ER-alpha
• interacts with ER-alpha N-terminal activation domain

Structure

• contains 1 RRM domain (RNA recognition motif)

Compartment

• nucleus, cytoplasm (putative)

Alternative splicing

named isoforms=10

More general terms

• RNA-binding motif protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23543
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23543
• UniProt: http://www.uniprot.org/uniprot/O43251.html