amphoterin-induced protein 2 (AMIGO-2, alivin-1, differentially expressed in gastric adenocarcinomas, DEGA, AMIGO2, ALI1)

Function

• required for depolarization-dependent survival of cultured cerebellar granule neurons
• may mediate homophilic & heterophilic cell-cell interaction with AMIGO1 or AMIGO3
• may contribute to signal transduction through its intracellular domain
• binds itself as well as AMIGO1 & AMIGO3

Structure

• belongs to the immunoglobulin superfamily, AMIGO family
• contains 1 Ig-like C2-type (immunoglobulin-like) domain
• contains 6 LRR (leucine-rich) repeats

Compartment

• cell membrane, nucleus
• restricted to somata of cerebellar & hippocampal neurons

Expression

• expressed in breast, ovary, cervix, uterus > lung, colon, rectum

Pathology

• differentially expressed in 56% of thyroid cancers 57% of pancreatic cancer 45% of stomach cancer

More general terms

• amigo protein (Amphoterin-induced protein, alivin)

Database

• UniProt: http://www.uniprot.org/uniprot/Q86SJ2.html