amphoterin-induced protein 1 (AMIGO-1, alivin-2, AMIGO1, ALI2, AMIGO, KIAA1163)

Function

• promotes growth & fasciculation of neurites from cultured hippocampal neurons
• may be involved in fasciculation as well as myelination of developing neural axons
• may have a role in regeneration as well as neural plasticity in the adult nervous system
• may mediate homophilic & heterophilic cell-cell interaction & may contribute to signal transduction through it intracellular domain
• binds itself as well as AMIGO2 & AMIGO3

Structure

• belongs to the immunoglobulin superfamily
• contains 1 Ig-like C2-type (immunoglobulin-like) domain
• contains 6 LRR repeats (leucine-rich repeats)

Compartment

• membrane
• associated with axons of neuronal cells

More general terms

• amigo protein (Amphoterin-induced protein, alivin)

Database

• UniProt: http://www.uniprot.org/uniprot/Q86WK6.html