manic fringe; beta-1,3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (MFNG)
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Function
- glycosyltransferase involved in the elongation of O-linked ligands to activate notch signaling
- manic fringe modifies Notch2 between the 23rd & 29th EGF repeats differing from lunatic fringe which modifies Notch2 between the N-terminus & the 15th EGF repeat thus resulting in a different modulation of Notch2 signalling
- fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity
- transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
Structure
belongs to the glycosyltransferase 31 family
Compartment
- Golgi membrane
- single-pass type 2 membrane protein (putative)
Alternative splicing
named isoforms=2
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O00587.html
- ↑ GGDB; Note: glycogene database http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- ↑ Functional glycomics gateway - GTase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_552
- ↑ Shimizu K et al. Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. J Biol Chem 276: 25753-8, 2001. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11346656
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4242