fringe homolog protein
Jump to navigation
Jump to search
Introduction
family of proteins which participate in the formation of boundaries between groups of cells during development.
Function
- Fringe proteins have fucose-specific beta 1,3-N-acetylglucos-aminyltransferase activity that catalyzes elongation of O-linked fucose on EGF repeats of Notch, which modulates Notch signaling.
- Fringe proteins can positively and negatively modulate the ability of Notch ligands to activate Notch receptors
- there are functional differences between various fringes in their ability to modulate different Notch ligand binding to Notch receptors
- Fringe beta 1,3-N-acetylglucosaminyltransferase activity is necessary but not sufficient to inhibit jagged 1 protein induced Notch signalling
- beta-4-galactosyltransferase-1 is also required[2]
Comparative biology
- originally named Drosophila protein; 3 mammalian homologs identified: lunatic fringe, radical fringe & manic fringe
More general terms
More specific terms
- lunatic fringe; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (LFNG)
- manic fringe; beta-1,3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (MFNG)
- radical fringe; beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (RFNG)