radical fringe; beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (RFNG)

Function

• glycosyltransferase that initiates elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of notch molecules
• may be involved in limb formation & in neurogenesis (putative)
• transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor

Cofactor: Mn+2 (putative)

Structure

• belongs to the glycosyltransferase 31 family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (putative)

Comparative biology

• in adult rat, radical fringe is expressed most abundantly in brain

More general terms

• fringe homolog protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5986
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5986
• OMIM: https://mirror.omim.org/entry/602578
• UniProt: http://www.uniprot.org/uniprot/Q9Y644.html