carbohydrate sulfotransferase 12; chondroitin 4-O-sulfotransferase 2; chondroitin 4-sulfotransferase 2; C4ST-2; C4ST2; sulfotransferase Hlo, CHSTC (CHST12)

Function

• catalyzes transfer of sulfate to position 4 of the N-acetylgalactosamine (galNAc) residue of chondroitin & to desulfated dermatan sulfate
• does not form 4,6-di-O-sulfated galNAc when chondroitin sulfate C is used as an acceptor

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

Structure

belongs to the sulfotransferase 2 family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (putative)

Expression

• widely expressed
• expressed a high level in spinal cord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen & fetal lung

More general terms

• carbohydrate sulfotransferase (CHST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55501
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55501
• OMIM: https://mirror.omim.org/entry/610129
• UniProt: http://www.uniprot.org/uniprot/Q9NRB3.html