calsyntenin-2; alcadein-gamma; alc-gamma (CLSTN2, CS2)

Function

• may modulate Ca+2-mediated postsynaptic signals
• proteolytically processed under normal cellular conditions
• primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (salc) & a short C-terminal transmembrane fragment (CTF1)
• secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-alc-gamma chain in the extracellular milieu & produces an intracellular fragment (alcICD). this processing is strongly suppressed in the tripartite complex formed with APBA2 & APP, which seems to prevent the association with PSEN1 (putative)

Structure

• binds synaptic Ca+2 with its cytoplasmic domain
• contains 2 cadherin domains

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)
• endoplasmic reticulum membrane
• Golgi membrane
• most prominent in the postsynaptic specializations of asymmetric (type 1) synapses with both axodendritic & axospinous localization (putative)

Expression

restricted to the brain

More general terms

• calsyntenin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64084
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64084
• OMIM: https://mirror.omim.org/entry/611323
• UniProt: http://www.uniprot.org/uniprot/Q9H4D0.html