relaxin receptor 1; leucine-rich repeat-containing G protein-coupled receptor 7 (LGR7, RXFP1)

Function

• receptor for relaxins
• activity is mediated by Gs proteins leading to stimulation of adenylate cyclase & an increase of cAMP
• binding of the ligand may also activate a tyrosine kinase pathway that inhibits activity of a phosphodiesterase that degrades cAMP

Structure

• belongs to the G-protein coupled receptor 1 family
• contains 1 LDL-receptor class A domain
• contains 10 LRR repeats (leucine-rich repeats)

Compartment

cell membrane

Alternative splicing

named isoforms=4

Expression

• expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin & heart
• not detected in spleen

More general terms

• leucine-rich repeat-containing G protein-coupled receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5935
• OMIM: https://mirror.omim.org/entry/606654
• UniProt: http://www.uniprot.org/uniprot/Q9HBX9.html