low density lipoprotein (LDL) receptor related protein (LRP) 12 (suppressor of tumorigenicity protein 7, ST7)

Function

• probable receptor
• may play role in the internalization of lipophilic molecules &/or signal transduction
• may act as a tumor suppressor
• may interact with GNB2L1, MADHIP & ITGB1BP3

Structure

• belongs to the LDLR family
• contains 2 CUB domains
• contains 5 LDL-receptor class A domains

Compartment

membrane, coated pit

Expression

• widely expressed in heart, skeletal muscle, brain, lung, placenta & pancreas
• not expressed in tissues consisting of a large number of epithelial cells, such as liver & kidney
• expressed at very low levels in a number of tumor-derived cell lines

More general terms

• low-density lipoprotein (LDL) receptor related protein (LRP)

Additional terms

• suppressor of tumorigenicity protein 7 (protein HELG) (ST7 FAM4A1 HELG RAY1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y561.html