zinc finger FYVE domain-containing protein 9; mothers against decapentaplegic homolog-interacting protein; Madh-interacting protein; smad anchor for receptor activation; receptor activation anchor; hSARA; Novel serine protease; NSP (ZFYVE9, MADHIP, SARA, SMADIP)

Function

• SARA binds with SMAD2 & SMAD3 & TGF-beta receptor, interacting with MH2 domain of SMAD2 & SMAD3
• phosphorylation of SMAD2 by TGF-beta receptor induces dissociation from SARA & formation of SMAD2/SMAD4 complexes & nuclear translocation
• role in recruiting unphosphorylated forms of SMAD2/SMAD3 to the TGF-beta receptor by controlling their subcellular localization & by interacting & colocalizing with the TGF-beta receptor

Structure

• FYVE domain mediates binding to phospholipids & targets SMADs to endosomes

Compartment

cytoplasm

Alternative splicing

• named isoforms=3
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• ubiquitous
• in the brain found primarily in the cerebrovascular smooth muscle cells & reactive astrocytes

More general terms

• zinc finger protein

Additional terms

• TGF-beta signalling

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9372
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9372
• OMIM: https://mirror.omim.org/entry/603755
• UniProt: http://www.uniprot.org/uniprot/O95405.html