low-density lipoprotein receptor-related protein 3; hLRp105 (LRP3)

Function

• probable receptor
• may be involved in the internalization of lipophilic molecules &/or signal transduction
• precise role is unclear,
• does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro
• binds GGA1 & GGA2 (putative)

Structure

• belongs to the LDLR family
• contains 2 CUB domains
• contains 4 LDL-receptor class A domains

Compartment

• membrane, coated pit (putative)

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in skeletal muscle, ovary > heart, brain, liver, pancreas, prostate, small intestine > testis, colon & leukocytes

More general terms

• low-density lipoprotein (LDL) receptor related protein (LRP)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4037
• OMIM: https://mirror.omim.org/entry/603159
• UniProt: http://www.uniprot.org/uniprot/O75074.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4037