vasoactive intestinal polypeptide receptor 1; VIP-R-1; pituitary adenylate cyclase-activating polypeptide type II receptor; PACAP type II receptor; PACAP-R-2 (VIPR1)

Function

• receptor for VIP
• activity is mediated by G proteins which activate adenylyl cyclase
• affinity is VIP = PACAP-27 > PACAP-38

Structure

belongs to the G-protein coupled receptor 2 family

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• expressed in lung, HT29 colonic epithelial cells, Raji B-lymphoblasts
• lesser expression in brain, heart, kidney, liver & placenta

More general terms

• vasoactive intestinal polypeptide [VIP] receptor
• pituitary adenyl cyclase activating polypeptide [PACAP] receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7433
• OMIM: https://mirror.omim.org/entry/192321
• UniProt: http://www.uniprot.org/uniprot/P32241.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7433