beta-3 adrenergic receptor; beta-3 adrenoreceptor; beta-3 adrenoceptor (ADRB3, ADRB3R, B3AR)

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Function

beta-adrenergic receptor
role in regulation of lipolysis & thermogenesis

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

Expression

expressed mainly in adipose tissues
expressed in brown adipose tissue

Polymorphism

variant Arg-64 seems to be associated with weight gain (obesity) & to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM)

More general terms

beta adrenergic receptor

References

↑ UniProt http://www.uniprot.org/uniprot/P13945.html
↑ SeattleSNPs http://pga.gs.washington.edu/data/adrb3/
↑ Emorine L, Blin N, Strosberg AD. The human beta 3-adrenoceptor: the search for a physiological function. Trends Pharmacol Sci. 1994 Jan;15(1):3-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8140656

Database

Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:155
OMIM: https://mirror.omim.org/entry/109691
UniProt: http://www.uniprot.org/uniprot/P13945.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=155

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