heparan sulfate glucosamine 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; h3-OST-3A (HS3ST3A1, 3OST3A1, HS3ST3A, UNQ2551/PRO6180)

Function

• transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate
• catalyzes O-sulfation of glucosamine in IdoUA2S-GlcNS & also in IdoUA2S-GlcNH2
• unlike HS3ST1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

3'-phosphoadenylyl sulfate + [[[A18449|heparan sulfate]]]-glucosamine = adenosine 3',5'-bisphosphate + [[[A18449|heparan sulfate]]]-glucosamine 3-sulfate

Structure

belongs to the sulfotransferase 1 family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (probable)

Expression

• ubiquitous
• expressed in heart & placenta > liver & kidney

Pathology

• the substrate-specific O-sulfation generates an enzyme- modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) & permits its entry.

More general terms

• heparan sulfate glucosamine 3-O-sulfotransferase (HS3ST)
• membrane protein

Additional terms

• glucosamine (Cosamin, Osteo-Bi-Flex)
• heparan sulfate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9955
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9955
• OMIM: https://mirror.omim.org/entry/604057
• UniProt: http://www.uniprot.org/uniprot/Q9Y663.html