sialic acid-binding Ig-like lectin 11; sialic acid-binding lectin 11; siglec-11 (SIGLEC11)

Function

• putative adhesion molecule that mediates sialic-acid dependent binding to cells
• preferentially binds to alpha-2,8-linked sialic acid
• the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
• in the immune response, may act as an inhibitory receptor upon ligand induced Tyr phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules
• phosphorylated on Tyr
• interacts with PTPN6/SHP-1 & PTPN11/SHP-2 upon phosphorylation

Structure

• contains 1 ITIM motif
• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 3 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• expressed by macrophages in various tissues including Kupffer cells
• also found in brain microglia

Notes

• uncertain whether Met-1 or Met-13 is the initiator

More general terms

• sialic acid-binding immunoglobulin-like lectin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114132
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114132
• OMIM: https://mirror.omim.org/entry/607157
• UniProt: http://www.uniprot.org/uniprot/Q96RL6.html