cyclin G1 (CCNG1, CCNG, CYCG1)

Function

• may play a role in growth regulation
• associated with G2/M phase arrest in response to DNA damage
• may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (putative)
• activated by actinomycin-D induced DNA damage

Structure

belongs to the cyclin family, cyclin G subfamily

Compartment

• nucleus
• DNA replication foci after DNA damage

Expression

• high levels in skeletal muscle, ovary, kidney & colon
• very low levels in normal cells during G1 phase, which increase as cells enter the S phase & stay high throughout the S & G2/M phases

Pathology

• in breast cancer cells consistent high levels are found throughout the cell cycle
• activated in breast & prostate cancer cells

More general terms

• cyclin G

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:900
• OMIM: https://mirror.omim.org/entry/601578
• UniProt: http://www.uniprot.org/uniprot/P51959.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=900