protein Jade-1 (PHD finger protein 17, PHF17, JADE1, KIAA1807)

Function

• transcriptional coactivator
• facilitates acetylation of nucleosomal histone H4 by HTATIP
• facilitates apoptosis
• renal tumor suppressor (putative)
• isoform 3 interacts with VHL & HTATI

Structure

• belongs to the JADE family
• contains 2 PHD-type zinc fingers required for transcriptional activity

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in kidney > pancreas, liver, heart

Pathology

• down-regulated in renal cancer cells

More general terms

• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6IE81.html