zinc finger MIZ domain-containing protein 1 (retinoic acid-induced protein 17, PIAS-like protein Zimp10, ZMIZ1, KIAA1224, RAI17, ZIMP10)

Function

• increases ligand-dependent transcriptional activity of AR
• promotes AR sumoylation
• stimulation of AR activity is dependent upon sumoylation
• interacts with AR
• does not interact with ESR1, NR3C1, PGR, THRB, VDR
• C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity; this activity is inhibited by the N-terminus in the full-length protein

Structure

• contains 1 SP-RING-type zinc finger

Compartment

nucleus; nuclear speckle, cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in ovary > prostate, spleen, testis > thymus, small intestine, colon, peripheral blood leukocytes

More general terms

• zinc finger protein
• retinoic acid-induced protein (RAI)

Database

• OMIM: https://mirror.omim.org/entry/607159
• UniProt: http://www.uniprot.org/uniprot/Q9ULJ6.html