Lin-28 homolog A (zinc finger CCHC domain-containing protein 1, LIN28, CSDD1, LIN28A, ZCCHC1)

Function

• negatively regulated by the interaction of microRNAs miR-125a, miR-125b
• at least 2 miRNA responsive elements (miREs) in the 3'-UTR of gene
• negatively regulated by retinoic acid

Structure

• belongs to the lin-28 family
• contains 2 CCHC-type zinc fingers
  • contains 1 CSD domain (cold-shock domain)

Compartment

cytoplasm

Expression

• expressed in embryonic stem cells (ES), placenta, testis
• expressed in fetal liver
• expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid

More general terms

• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H9Z2.html