zinc finger BED domain-containing protein 1 (dREF homolog, Ac-like transposable element, ZBED1, ALTE, DREF, KIAA0785, TRAMP)

Function

• binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in promoter regions of genes related to cell proliferation
• binds to the histone H1 promoter & stimulates transcription

Structure

• 1st identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity
• homodimer
• contains 1 BED-type zinc finger

Compartment

nucleus, in granular structures

Expression

• ubiquitously expressed at low levels
• expression is highest in skeletal muscle, heart, spleen, placenta
• expression is linked to the cell cycle:
  • low in serum-starved fibroblasts
  • increasing during the G1/S phase
  • highest during the S/G2 phase
  • then decreases in M phase

More general terms

• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/300178
• UniProt: http://www.uniprot.org/uniprot/O96006.html