MORC family CW-type zinc finger protein 3; zinc finger CW-type coiled-coil domain protein 3 (MORC3, KIAA0136, ZCWCC3. NXP2)
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Function
- nuclear factor
- forms MORC3-nuclear bodies via an ATP-dependent mechanism
- sumoylated MORC3-nuclear bodies can also associate with PML-nuclear bodies
- recruits TP53 & SP100 to PML-nuclear bodies, thus regulating TP53 activity
- binds RNA in vitro[8]
- sumoylation is involved in interaction with PML & localization to PML nuclear bodies
- interacts with PML (via SUMO-interacting motif)[2][5]
- interacts with PT53[2]
Structure
- homodimer . the sumoylated form
- contains 1 CW-type zinc finger
Compartment
nucleus, nucleoplasm, nucleus matrix
Expression
- expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver
- not expressed in kidney
Pathology
- may be required for influenza A transcription during viral infection
- interacts with influenza A virus PA & PB1 polymerase subunits during infection
- autoautibodies (Mj Ab) in polymyositis/dermatomyositis[9]
Laboratory
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q14149.html
- ↑ Jump up to: 2.0 2.1 2.2 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17332504
- ↑ PMID: https://www.ncbi.nlm.nih.gov/pubmed/332504
- ↑ PMID: https://www.ncbi.nlm.nih.gov/pubmed/26202233
- ↑ Jump up to: 5.0 5.1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20501696
- ↑ PMID: https://www.ncbi.nlm.nih.gov/pubmed/501696
- ↑ PMID: https://www.ncbi.nlm.nih.gov/pubmed/20501696
- ↑ Jump up to: 8.0 8.1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11927593
- ↑ Jump up to: 9.0 9.1 Ceribelli A, Fredi M, Taraborelli M, Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Arthritis Res Ther. 2012 Apr 30;14(2):R97. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22546500 Free PMC Article