inhibitor of growth protein 2; inhibitor of growth 1-like protein; ING1Lp; p32; p33ING2 (ING2, ING1L)

Function

• seems to be involved in p53/TP53 activation & p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53
• component of a msin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones
• ING2 activity seems to be modulated by binding to phosphoinositides
• interacts with H3K4me3 & to a lesser extent with H3K4me2

Structure

• the PHD-type Zn+2 finger mediates the binding to H3K4me3
• the polybasic region (PBR) is responsive to the binding to phosphoinositides, including phosphatidylinositol-5-phosphate (Ptdins(5)P)
• belongs to the ING family
• contains 1 PHD-type Zn+2 finger

Compartment

• nucleus
• predominantly nuclear
• localized to chromatin & nuclear matrix
• upon reduced Ptdins(5)P levels, seems to be released from chromatin &, at least partially, translocated to the cytoplasm

Expression

• widely expressed
• induced by the DNA-damaging agents etoposide & neocarzinostatin

Pathology

• higher expression in colon-cancer than in normal colon

More general terms

• inhibitor of growth protein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3622
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3622
• OMIM: https://mirror.omim.org/entry/604215
• UniProt: http://www.uniprot.org/uniprot/Q9H160.html