ubiquitin thioesterase ZRANB1; TRAF-binding domain-containing protein; htrabid; zinc finger Ran-binding domain-containing protein 1 (ZRANB1, TRABID)

Function

• positive regulator of the Wnt signaling pathway
• specifically cleaves Lys-63-linked ubiquitin chains
• acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription
• role in the regulation of cell morphology & cytoskeletal organization
• required in stress fiber dynamics & cell migration
• may modulate TNF-alpha signaling
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• interacts with APC & TRAF6

Structure

• the OTU domain mediates the deubiquitinating activity
• the RanBP2-type Zn+2 fingers mediate the specific interaction with Lys-63-linked ubiquitin
• belongs to the peptidase C64 family
• contains 1 OTU domain
• contains 3 RanBP2-type Zn+2 fingers

Compartment

• cytoplasm, nucleus
• enriched in punctate localization in the cytoplasm

Expression

widely expressed

More general terms

• zinc finger protein
• thiol esterase or thioesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54764
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54764
• OMIM: https://mirror.omim.org/entry/611749
• UniProt: http://www.uniprot.org/uniprot/Q9UGI0.html