deltex homolog

Function

• regulator of notch signaling
• probably acts both as a positive & negative regulator of notch, depending on the developmental & cell context
• functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity
• homomultimer
• members may form a heteromultimer with other members of the deltex family
• interacts with NOTCH1

Structure

• belongs to the deltex family
• contains 1 RING-type Zn+2 finger

More general terms

• ring finger protein

More specific terms

• protein deltex-1; deltex1; hDTX1 (DTX1)
• protein deltex-2; deltex2; hDTX2; RING finger protein 58 (DTX2, KIAA1528, RNF58)
• protein deltex-3; deltex3; RING finger protein 154 (DTX3, RNF154)
• protein deltex-4 (deltex-4, deltex4, RING finger protein 155, DTX4, KIAA0937, RNF155)