protein deltex-2; deltex2; hDTX2; RING finger protein 58 (DTX2, KIAA1528, RNF58)

Function

• regulator of notch signaling
• probably acts both as a positive & negative regulator of notch, depending on the developmental & cell context
• mediates anti-neural activity of notch, possibly by inhibiting transcriptional activation mediated by MATCH1
• functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity
• homomultimer
• may form a heteromultimer with other members of the deltex family
• interacts with NOTCH1

Structure

• the WWE domains are thought to mediate some protein-protein interaction, & are frequently found in ubiquitin ligases
• belongs to the deltex family
• contains 1 RING-type Zn+2 finger
• contains 2 WWE domains

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic
• partially nuclear

Alternative splicing

named isoforms=2

More general terms

• deltex homolog
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=113878
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:113878
• OMIM: https://mirror.omim.org/entry/613141
• UniProt: http://www.uniprot.org/uniprot/Q86UW9.html