protein deltex-3; deltex3; RING finger protein 154 (DTX3, RNF154)

Function

• regulator of notch signaling
• probably acts both as a positive & negative regulator of notch, depending on the developmental & cell context
• functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity
• homomultimer
• may form a heteromultimer with other members of the deltex family
• interacts with NOTCH1

Structure

• belongs to the deltex family
• contains 1 RING-type Zn+2 finger

Compartment

cytoplasm (probable)

Alternative splicing

named isoforms=2

More general terms

• deltex homolog

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=196403
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:196403
• OMIM: https://mirror.omim.org/entry/613142
• UniProt: http://www.uniprot.org/uniprot/Q8N9I9.html