integrin beta-1-binding protein 1; integrin cytoplasmic domain-associated protein 1; ICAP-1 (ITGB1BP1 ICAP1)

Function

• may play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion
• isoform 1 appears to be phosphorylated
• the degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction

Structure

contains 1 PID domain

Compartment

cytoplasm

Alternative splicing

• named isoforms=2
• at least 1 isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• expressed in intestine, colon, testis, ovary, thymus, spleen & prostate

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9270
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9270
• OMIM: https://mirror.omim.org/entry/607153
• UniProt: http://www.uniprot.org/uniprot/O14713.html