zinc finger protein 397; zinc finger & SCAN domain-containing protein 15; zinc finger protein 47 (ZNF397, ZNF47, ZSCAN15)

Function

• isoform 3 acts as a DNA-dependent transcriptional repressor
• phosphorylated upon DNA damage, probably by ATM or ATR
• isoforms 1 & 3 can form homdimers or heterodimers
• isoform 1 homodimer is dependent on the presence of the SCAN domain

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 9 C2H2-type Zn+2 fingers
• contains 1 SCAN box domain

Compartment

• isoform 1: nucleus
• isoform 3: nucleus. cytoplasm

Alternative splicing

named isoforms=3

Expression

• expressed in testis > skeletal muscle, pancreas, prostate > heart, placenta, liver, kidney, spleen, thymus, small intestine

Notes

Ref.1 (AAN65175) sequence differs from that shown due to a frameshift in position 194

More general terms

• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84307
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84307
• OMIM: https://mirror.omim.org/entry/609601
• UniProt: http://www.uniprot.org/uniprot/Q8NF99.html