zinc finger protein 382; KRAB/zinc finger suppressor protein 1; KS1; multiple zinc finger & krueppel-associated box protein KS1 (ZNF382)

Function

• sequence-specific transcriptional repressor (putative)
• interacts with TRIM28
  • enhances the transcriptional repressor activity (putative)

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 10 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=3

Expression

• specifically expressed in heart
• weaker expression in skeletal muscle
• primarily detected in 34 day-old embryos
• widely expressed at different levels during embryonic development
  • in the embryo, expressed in cerebellum, kidney, cerebrum > lung, heart, skeletal muscle, tongue, adrenal gland

More general terms

• C2H2 type zinc finger protein
• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84911
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84911
• OMIM: https://mirror.omim.org/entry/609516
• UniProt: http://www.uniprot.org/uniprot/Q96SR6.html