zinc finger protein 378; palmitoyltransferase ZDHHC8; zinc finger DHHC domain-containing protein 8; DHHC-8 (ZDHHC8, KIAA1292, ZDHHCL1, ZNF378)

Function

• palmitoyltransferase involved in glutamatergic transmission
• mediates palmitoylation of ABCA1

palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA

Structure

• the DHHC domain is required for palmitoyltransferase activity (putative)
• belongs to the DHHC palmitoyltransferase family ERF2/ZDHHC9 subfamily
• contains 1 DHHC-type Zn+2 finger

Compartment

• cytoplasmic vesicle membrane
• multi-pass membrane protein (putative)

Alternative splicing

named isoforms=3

More general terms

• S-palmitoyl transferase
• zinc finger protein
• phosphoprotein
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29801
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29801
• OMIM: https://mirror.omim.org/entry/608784
• UniProt: http://www.uniprot.org/uniprot/Q9ULC8.html