zinc finger protein 365; protein su48 (ZNF365, KIAA0844)

Function

• phosphorylated upon DNA damage, probably by ATM or ATR
• homodimer
• interacts with NDE1 & NDEL1
• does not interact with TUBG1

Compartment

• cytoplasm, cytoskeleton, centrosome
• localizes to the centrosome at all stages of the cell cycle

Alternative splicing

named isoforms=6

Expression

• isoform 1 is expressed in brain
• isoform 2 is expressed in placenta > lung, liver
• isoform 3 is expressed in kidney, pancreas

Comparative biology

• isoform 4 (talanin) of ZNF365 does not exist in rodents (see talanin)

More general terms

• zinc finger protein

More specific terms

• talanin

Database

• OMIM: https://mirror.omim.org/entry/607818
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22891
• UniProt: http://www.uniprot.org/uniprot/Q70YC5.html
• UniProt: http://www.uniprot.org/uniprot/Q70YC4.html