talanin

Function

• uric acid excretion (putative)

Alternative splicing

named isoforms=6

Expression

• isoform 4 (talanin) is expressed in placenta, lung, kidney & pancreas

Polymorphism

• polymorphism Thr-62 is associated with susceptibility to uric acid nephrolithiasis

Comparative biology

• isoform 4 (talanin) of ZNF365 does not exist in rodents
• in primates, a canonical intron-exon structure exists, with several stop codons preventing talanin production in old world & new world monkeys
• it is hypothesized that isoform 4 emerged during primate evolution from a noncoding genomic sequence

More general terms

• zinc finger protein 365; protein su48 (ZNF365, KIAA0844)

Additional terms

• nephrolithiasis; kidney stone

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22891
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22891
• OMIM: https://mirror.omim.org/entry/605990
• OMIM: https://mirror.omim.org/entry/607818
• UniProt: http://www.uniprot.org/uniprot/Q70YC4.html