ariadne-2 protein homolog; ARI-2; triad1 protein (ARIH2, ARI2, TRIAD1, HT005)

Function

• might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, & then transfers it to substrates
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with UBE2L3 (putative)

Structure

• belongs to the RBR family, Ariadne subfamily
• contains 1 IBR-type Zn+2 finger
• contains 2 RING-type Zn+2 fingers

Compartment

nucleus

More general terms

• nuclear protein
• ring finger protein
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10425
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10425
• OMIM: https://mirror.omim.org/entry/605615
• UniProt: http://www.uniprot.org/uniprot/O95376.html