liver glutaminase

Function

• role in the regulation of glutamine catabolism
• interacts with the PDZ domain of the syntrophin SNTA1
• interacts with the PDZ domain of TAX1BP3

L-glutamine + H2O <--> L-glutamate + NH3

Structure

• belongs to the glutaminase family
• contains 2 ANK repeats

Compartment

mitochondria

Expression

• expressed in liver, brain & pancreas
• not expressed in heart, placenta, lung, skeletal muscle & kidney

Genetics

gene locus: 12q13

More general terms

• glutaminase

Database

• OMIM: https://mirror.omim.org/entry/606365
• UniProt: http://www.uniprot.org/uniprot/Q9UI32.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27165