retinoblastoma binding protein 6; RB binding protein 6; p53-associated cellular protein of testis; proliferation potential-related protein; protein P2P-R; retinoblastoma-binding Q protein 1; protein RBQ-1 (RBBP6, P2PR, PACT, RBQ1, My038)

Function

• interacts with p53/TP53 & RB1 (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 1 CCHC-type Zn+2 finger
• contains 1 DWNN domain
• contains 1 RING-type Zn+2 finger

Compartment

• nucleus, nucleolus
• colocalizes with mitotic chromosomes

Alternative splicing

named isoforms=4

Expression

• highly expressed in the placenta & testis
• expressed at lower levels in the brain, heart, kidney, liver & lung

Pathology

• overexpressed in esophageal cancer

More general terms

• retinoblastoma-binding protein
• ring finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/600938
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5930
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5930
• UniProt: http://www.uniprot.org/uniprot/Q7Z6E9.html