Fanconi anemia-associated protein of 24 kD (FAAP24, C19orf40)

Function

• role in DNA repair through recruitment of FA core complex to damaged DNA
• regulates FANCD2 monoubiquitylation upon DNA damage
• induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed
• targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA
• belongs to the multisubunit FA complex
• interacts with FANCM

Structure

• C-terminal region is distantly related to RuvA domain 2, a DNA-binding domain

Compartment

nucleus

More general terms

• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BTP7.html