zinc finger protein 22; zinc finger protein KOX15; Krox-26 protein (ZNF22, KOX15, KROX26)

Function

• binds DNA through the consensus sequence 5'-CAATG-3'
• may be involved in transcriptional regulation
• may play a role in tooth formation (putative)

Structure

-belongs to the krueppel C2H2-type Zn+2-finger protein family

• contains 5 C2H2-type Zn+2 fingers

Compartment

nucleus (putative)

Expression

• in the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium & muscle, & craniofacial bone osteoblasts
• in the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney & liver > spleen, thymus & brain > endoderm-derived tissues such as intestine & colon

More general terms

• DNA-binding protein
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7570
• OMIM: https://mirror.omim.org/entry/194529
• UniProt: http://www.uniprot.org/uniprot/P17026.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7570