DNA-binding protein SMUBP-2; ATP-dependent helicase IGHMBP2; immunoglobulin mu-binding protein 2; SMUBP-2; glial factor 1; GF-1 (IGHMBP2, SMBP2, SMUBP2)
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Function
- DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region
- preferentially binds to the motif 5'-GGGCT-3'
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure
- belongs to the DNA2/NAM7 helicase family
- contains 1 AN1-type Zn+2 finger
- contains 1 R3H domain
Compartment
Expression
In all tissues examined
Pathology
- defects in IGHMBP2 are the cause of spinal muscle atrophy with respiratory distress type 1
- stimulates transcription of human neurotropic virus JCV
More general terms
- helicase (DNA unwinding protein, DNA untwisting protein)
- DNA-binding protein
- phosphoprotein
- zinc finger protein