nucleoporin NUP85 (nuclear pore complex protein Nup85, 85kDa nucleoporin, nucleoporin Nup75, pericentrin-1, FROUNT, NUP85, NUP75, PCNT1)

Function

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• essential component of the nuclear pore complex, Nup107-160 subcomplex
• seems to be required for nuclear pore complex assembly & maintenance
• NUP85 is required for membrane clustering of CCL2- activated CCR2
• seems to be involved in CCR2-mediated chemotaxis of monocytes & may link activated CCR2 to the PI-3-kinase - Rac-lammellipodium protrusion cascade
• interacts with NUP160, NUP133 & SEC13
• interacts with NUP37, NUP107 & NUP43
• interacts with CCR2

Structure

belongs to the nucleoporin Nup85 family

Compartment

• nucleus, nuclear pore complex
• kinetochore spindle
• cytoplasm
• during mitosis, localizes to the kinetochores & spindle poles
• upon CCl2 stimulation, translocates from the cytoplasm to the membrane & colocalizes with CCR2 at the front of migrating cells

More general terms

• nucleoporin (nuclear pore complex protein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7990
• OMIM: https://mirror.omim.org/entry/170285
• UniProt: http://www.uniprot.org/uniprot/Q9BW27.html