myosin heavy chain 10; myosin-10; myosin heavy chain, non-muscle IIb; non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB; cellular myosin heavy chain, type B; non-muscle myosin heavy chain B; NMMHC-B (MYH10)

Function

• cellular myosin
• appears to play a role in cytokinesis, cell shape, & specialized functions such as secretion & capping
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• myosin is a hexameric protein that consists of
  • 2 myosin heavy chain subunits
  • 2 myosin essential light chain subunits
  • 2 myosin regulatory light chain subunits
• rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
• contains 1 IQ domain
• contains 1 myosin head-like domain

Alternative splicing

named isoforms=3

Expression

• found in non muscle tissue
• isoform 1 is expressed predominantly in cerebellum & spinal cord
• isoform 2 is expressed in cerebrum & retina
• isoform 3 is expressed in the cerebrum & to a much lower extent in cerebellum

More general terms

• myosin heavy chain

Additional terms

• myosin
• myosin-10; unconventional myosin-10 (MYO10, KIAA0799)

Database

• UniProt: http://www.uniprot.org/uniprot/P35580.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4628
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4628
• OMIM: https://mirror.omim.org/entry/160776