protein S100-A11; S100 Ca+2-binding protein A11; protein S100C; calgizzarin; MLN 70 (S100A11, MLN70, S100C)

Function

• facilitates differentiation & cornification of keratinocytes
• phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization & promotes association with NCL/nucleolin which induces nuclear translocation
• binds 2 Ca+2 with an affinity similar to that of the S-100 proteins (putative)

Structure

• homodimer; disulfide-linked
• belongs to the S-100 family
• contains 2 EF-hand domains

Compartment

cytoplasm, nucleus

More general terms

• S100 Ca+2-binding protein A

Additional terms

• S100 Ca+2-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P31949.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6282
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6282
• OMIM: https://mirror.omim.org/entry/603114