tRNA-splicing endonuclease subunit sen2; tRNA-intron endonuclease sen2; Hssen2 (TSEN2 SEN2)

Function

• one of 2 catalytic subunits of tRNA-splicing endonuclease
• isoform 2 is a component of a complex with SEN54, but low level of SEN15 & SEN34
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the tRNA-intron endonuclease family

Compartment

nuclear; may be transiently localized in nucleolus

Alternative splicing

named isoforms=3

Expression

• isoform 1 & isoform 2 are widely expressed at very low level

Pathology

• defects in TSEN2 are the cause of pontocerebellar hypoplasia type 2B

More general terms

• endonuclease
• enzyme catalytic subunit
• nuclear protein
• phosphoprotein

Component of

• tRNA-splicing endonuclease complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80746
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80746
• OMIM: https://mirror.omim.org/entry/608753
• OMIM: https://mirror.omim.org/entry/612389
• UniProt: http://www.uniprot.org/uniprot/Q8NCE0.html