tRNA-splicing endonuclease subunit Sen54 (tRNA-intron endonuclease Sen54, HsSen54, TSEN54, SEN54)

Function

• non-catalytic subunit of the tRNA-splicing endonuclease
• also belongs to a complex containing isoform 2 of SEN2
• phosphorylated upon DNA damage, probably by ATM or ATR

Compartment

• nucleus, nucleolus (probable)
• may be transiently localized in the nucleolus

Alternative splicing

named isoforms=2

More general terms

• enzyme regulatory subunit
• phosphoprotein

Component of

• tRNA-splicing endonuclease complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2839
• OMIM: https://mirror.omim.org/entry/608755
• UniProt: http://www.uniprot.org/uniprot/Q7Z6J9.html