dihydropyrimidinase-related protein 4; DRP-4; collapsin response mediator protein 3; CRMP-3; UNC33-like phosphoprotein 4; ULIP-4 (DPYSL4, CRMP3, ULIP4)

Function

• necessary for signaling by class 3 semaphorins & subsequent remodeling of the cytoskeleton
• role in axon guidance, neuronal growth cone collapse & cell migration
• phosphorylated upon DNA damage, probably by ATM or ATR
• homotetramer, & heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5
• interacts with PLEXA1 (putative)

Structure

• belongs to the DHOase family, hydantoinase/dihydropyrimidinase subfamily
• lacks most of the conserved residues essential for binding the metal cofactor & hence for dihydropyrimidinase activity

Compartment

cytoplasm (putative)

More general terms

• dihydropyrimidinase related protein

Additional terms

• dihydropyrimidinase; DHP; DHPase; dihydropyrimidine amidohydrolase; hydantoinase (DPYS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10570
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10570
• OMIM: https://mirror.omim.org/entry/608407
• UniProt: http://www.uniprot.org/uniprot/O14531.html