dihydropyrimidinase-related protein 1; DRP-1; collapsin response mediator protein 1; CRMP-1; Unc-33-like phosphoprotein 3; ULIP-3 (CRMP1 DPYSL1 ULIP3)

Function

• necessary for signaling by class 3 semaphorins & subsequent remodeling of the cytoskeleton
• role in axon guidance, invasive growth & cell migration
• homotetramer, & heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5
• interacts with PLXNA1 (putative)

Structure

• belongs to the DHOase family, hydantoinase/dihydropyrimidinase subfamily
• lacks most of the conserved residues essential for binding the metal cofactor & hence for dihydropyrimidinase activity

Compartment

• cytoplasm. cytoplasm, cytoskeleton
• centrosome, spindle
• associated with centrosomes & the mitotic spindle during metaphase

Expression

brain

More general terms

• dihydropyrimidinase related protein

Additional terms

• dihydropyrimidinase; DHP; DHPase; dihydropyrimidine amidohydrolase; hydantoinase (DPYS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1400
• OMIM: https://mirror.omim.org/entry/602462
• UniProt: http://www.uniprot.org/uniprot/Q14194.html