dihydropyrimidinase-related protein 3; DRP-3; collapsin response mediator protein 4; CRMP-4; Unc-33-like phosphoprotein 1; ULIP-1 (DPYSL3, CRMP4, DRP3, ULIP, ULIP1)

Function

• necessary for signaling by class 3 semaphorins & subsequent remodeling of the cytoskeleton
• role in axon guidance, neuronal growth cone collapse & cell migration
• homotetramer, & heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (putative)
• interacts with synaptic vesicle protein 2 & SH3 domain A of intersectin-1 (putative)

Structure

• belongs to the DHOase family hydantoinase/dihydropyrimidinase subfamily
• lacks most of the conserved residues essential for binding the metal cofactor & hence for dihydropyrimidinase activity

Compartment

• cytoplasm, cell projection, growth cone (putative)
• colocalizes with synaptic vesicle protein 2 in the central region of the growth cone

Expression

• mainly expressed in heart & skeletal muscle
• also strongly expressed in fetal brain & spinal cord

More general terms

• dihydropyrimidinase related protein

Additional terms

• dihydropyrimidinase; DHP; DHPase; dihydropyrimidine amidohydrolase; hydantoinase (DPYS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1809
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1809
• OMIM: https://mirror.omim.org/entry/601168
• UniProt: http://www.uniprot.org/uniprot/Q14195.html