complexin-1; complexin I; CPX I; synaphin-2 (CPLX1)

Function

• positively regulates a late step in synaptic vesicle exocytosis
• also involved in glucose-induced secretion of insulin by pancreatic beta-cells (putative)
• binds to the SNARE core complex containing SNAP25, VAMP2 & STX1A (putative)

Structure

belongs to the complexin/synaphin family

Compartment

• cytoplasm, cytosol (putative)
• enriched at synaptic-releasing sites in mature neurons

Expression

• expressed in nervous system
• in hippocampus & cerebellum, expressed mainly by inhibitory neurons

Pathology

• overexpressed in substantia nigra from patients with Parkinson disease

More general terms

• complexin (synaphin)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10815
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10815
• OMIM: https://mirror.omim.org/entry/605032
• UniProt: http://www.uniprot.org/uniprot/O14810.html