regulator of G-protein signaling 6; S914 (RGS6)

Function

• inhibits signal transduction by increasing GTPase activity of Gp-alpha subunits thus increasing the amount of inactive GDP-bound form
• activity on Go-alpha is specifically enhanced by the RGS6/Gbeta5 dimer
• heterodimer with Gbeta5
• interacts with RGS7BP, regulating subcellular location of the RGS6/Gbeta5 dimer (putative)

Structure

• contains 1 DEP domain
• contains 1 G protein gamma domain
• contains 1 RGS domain

Compartment

• cytoplasm, peripheral membrane

Alternative splicing

named isoforms=11

More general terms

• regulator of G-protein signaling

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9628
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9628
• OMIM: https://mirror.omim.org/entry/603894
• UniProt: http://www.uniprot.org/uniprot/P49758.html