GTP-binding regulatory protein beta-5; transducin beta-5 (GNB5)

Function

• G-beta & G-gamma chains are required for
  • GTPase activity of heterotrimeric G proteins
  • replacement of GDP by GTP
  • G protein-effector interaction
• component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) & RGS9BP (putative)

Structure

• G proteins are composed of 3 units G-alpha, G-beta & G-gamma
• belongs to the WD repeat G protein beta family
• contains 7 WD repeats

Alternative splicing

named isoforms=2

Expression

expressed in multiple tissues

More general terms

• GTP-binding regulatory protein beta

Additional terms

• G-beta/gamma
• G-protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10681
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10681
• OMIM: https://mirror.omim.org/entry/604447
• UniProt: http://www.uniprot.org/uniprot/O14775.html